Wineskin Winery allows you to make Wineskin wrappers, as well as manage/download Wineskin Engines, Wrapper updates, and even custom build engines from Wine source.
Wineskin wrappers are used to make a Windows application or game into a Mac app. it uses Wine at its heart to run the software, but the finished product is a Mac app that runs just like a native app. Can be used to make ports of Windows software to Macs.
Designed with gaming in mind, with true fullscreen gaming and resolution changes supported. Has its own custom build of XQuartz, does not use systems X11.app.
Wineskin (and Wineskin Winery) are Open Source LGPL licensed products.
Wineskin Winery, and Wineskin wrappers themselves require Mac OS X 10.5+, but requirements of running a wrapper may change depending on what Windows software it is running.